SCHEMBL19088057

SCHEMBL19088057

Cc1c(CCNCl)c2cc(Br)ccc2n1Cc1ccccc1Cl

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.56
CYP3A4 P08684 1/20 0.56
CYP2D6 P10635 1/20 0.56
CYP2C19 P33261 1/20 0.56
PLA2G2A P14555 3/20 0.48
L3MBTL1 Q9Y468 1/20 0.46
PTGS2 P35354 2/20 0.43
GFER P55789 1/20 0.41
PTGES O14684 1/20 0.40
ALOX5 P09917 1/20 0.40
PTGDR2 Q9Y5Y4 1/20 0.40
CNR2 P34972 3/20 0.39
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 1/20 0.39
KMT2A Q03164 1/20 0.39
BRD4 O60885 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19064537 0.87 CYP1A2 (0.72) CYP1A2CYP3A4CYP2D6CYP2C19PLA2G2A
SCHEMBL19088055 0.86 GFER (0.54) CYP1A2CYP3A4CYP2D6CYP2C19PLA2G2A
SCHEMBL19088135 0.73 CYP1A2 (0.51) CYP1A2CYP3A4CYP2D6CYP2C19PLA2G2A
SCHEMBL19088144 0.73 CYP1A2 (0.64) CYP1A2CYP3A4CYP2D6CYP2C19PLA2G2A
SCHEMBL19087997 0.73 CYP1A2 (0.61) CYP1A2CYP3A4CYP2D6CYP2C19PLA2G2A
SCHEMBL16027044 0.72 CYP1A2 (1.00) CYP1A2CYP3A4CYP2D6CYP2C19PLA2G2A
SCHEMBL19064547 0.72 CYP1A2 (0.71) CYP1A2CYP3A4CYP2D6CYP2C19PLA2G2A
Hydrochloric Acid SCHEMBL19064529 0.71 CYP1A2 (0.98) CYP1A2CYP3A4CYP2D6CYP2C19PLA2G2A
SCHEMBL3855495 0.70 PLA2G2A (0.65) PLA2G2APTGS2PTGDR2ALDH1A1KMT2A
SCHEMBL19088165 0.70 GFER (0.74) PLA2G2AGFERPTGDR2MEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3397254-B1 TRYPTAMINE-BASED SHIP INHIBITORS FOR THE TREATMENT OF CANCER UNIV NEW YORK STATE RES FOUND (US) 2021-10-27 EP disclosed
WO-2017117581-A1 TRYPTAMINE-BASED SHIP INHIBITORS FOR THE TREATMENT OF CANCER THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2017-07-06 WO disclosed