Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.42 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 8/20 | 0.40 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20655716 | 0.84 | EGFR (0.56) | EGFR | |
| SCHEMBL19089633 | 0.81 | EGFR (0.39) | FGFR3CYP3A4EPHB4EGFRERBB3 | |
| SCHEMBL19089675 | 0.79 | EGFR (0.49) | INSREPHB4KDREGFRERBB3 | |
| SCHEMBL19089359 | 0.78 | EGFR (0.36) | FGFR3CYP3A4EPHB4EGFRERBB3 | |
| SCHEMBL19089361 | 0.78 | EPHA2 (0.48) | EPHB4EPHA2KDRDUSP3PTPN5 | |
| SCHEMBL19089627 | 0.78 | EPHA2 (0.39) | EPHB4EPHA2KDREGFRERBB3 | |
| SCHEMBL19089341 | 0.74 | EGFR (0.41) | EPHB4EGFRERBB3 | |
| SCHEMBL19089358 | 0.74 | EGFR (0.39) | EGFRERBB3 | |
| SCHEMBL19089356 | 0.74 | EGFR (0.39) | EGFRERBB3 | |
| SCHEMBL19089357 | 0.73 | EGFR (0.42) | FGFR3CYP3A4EGFRERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114500-A1 | ACRYLANILIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATIONS THEREOF IN PHARMACY | 恩瑞生物医药科技（上海）有限公司 | 2017-07-06 | — | — | WO | disclosed |