Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.52 |
| ▸ | BRD2 | P25440 | 2/20 | 0.52 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TPH2 | Q8IWU9 | 12/20 | 0.41 |
| ▸ | TPH1 | P17752 | 11/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21389590 | 0.93 | BRD4 (0.61) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL19090310 | 0.85 | BRD4 (0.53) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL19090447 | 0.79 | BRD4 (0.62) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL23731010 | 0.74 | MEN1 (0.56) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL23730961 | 0.74 | MEN1 (0.65) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL19090312 | 0.72 | MEN1 (0.49) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL19090215 | 0.71 | BRD4 (0.72) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL19090452 | 0.71 | BRD4 (0.87) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL19090404 | 0.71 | MAPT (0.49) | BRD4BRD2BRD3MEN1KMT2A | |
| SCHEMBL19090207 | 0.70 | BRD4 (0.86) | BRD4BRD2BRD3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114843-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2017-07-06 | — | — | WO | disclosed |