Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TPH1 | P17752 | 4/20 | 0.43 |
| ▸ | TPH2 | Q8IWU9 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21389516 | 0.93 | BRD4 (0.54) | MAPTALDH1A1LMNAALOX15POLB | |
| SCHEMBL19090398 | 0.86 | ALDH1A1 (0.52) | MAPTALDH1A1LMNAALOX15POLB | |
| SCHEMBL19090331 | 0.78 | MAPT (0.47) | MAPTALDH1A1LMNAALOX15POLB | |
| SCHEMBL19090312 | 0.75 | MEN1 (0.49) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL23731010 | 0.72 | MEN1 (0.56) | TSHRNPSR1MEN1KMT2ABRD4 | |
| SCHEMBL23730961 | 0.72 | MEN1 (0.65) | TSHRNPSR1MEN1KMT2ABRD4 | |
| SCHEMBL21389508 | 0.72 | MAPT (0.55) | MAPTALDH1A1LMNATSHRHPGD | |
| SCHEMBL19090447 | 0.71 | BRD4 (0.62) | LMNAALOX15MEN1KMT2ABRD4 | |
| SCHEMBL19090219 | 0.71 | BRD4 (0.52) | ALDH1A1TSHRHPGDNPSR1MEN1 | |
| SCHEMBL21389536 | 0.70 | BRD4 (0.57) | ALDH1A1HPGDGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114843-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2017-07-06 | — | — | WO | disclosed |