Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | BRD2 | P25440 | 1/20 | 0.48 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.48 |
| ▸ | TPH2 | Q8IWU9 | 13/20 | 0.47 |
| ▸ | TPH1 | P17752 | 12/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21389561 | 0.93 | BRD4 (0.56) | MEN1KMT2ABRD4BRD2BRD3 | |
| SCHEMBL21389530 | 0.87 | BRD4 (0.56) | MEN1KMT2ABRD4BRD2BRD3 | |
| SCHEMBL19090319 | 0.86 | BRD4 (0.46) | MEN1KMT2ABRD4BRD2BRD3 | |
| SCHEMBL19090329 | 0.81 | BRD4 (0.46) | MEN1KMT2ABRD4BRD2BRD3 | |
| SCHEMBL21389571 | 0.80 | BRD4 (0.46) | MEN1KMT2ABRD4BRD2BRD3 | |
| SCHEMBL21389508 | 0.79 | MAPT (0.55) | MEN1KMT2ABRD4BRD2BRD3 | |
| SCHEMBL19090318 | 0.78 | ELANE (0.41) | MEN1KMT2AELANECYP1A2CYP2C9 | |
| SCHEMBL21389536 | 0.78 | BRD4 (0.57) | MEN1KMT2ABRD4BRD2BRD3 | |
| SCHEMBL21389588 | 0.76 | BRD4 (0.56) | MEN1KMT2ABRD4BRD2BRD3 | |
| SCHEMBL23731052 | 0.76 | BRD4 (0.57) | MEN1KMT2ABRD4BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017114843-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2017-07-06 | — | — | WO | disclosed |