Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | KCNA5 | P22460 | 7/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19090261 | 1.00 | TSHR (0.55) | TSHRKCNA5KCNH2KCNE1CYP2D6 | |
| SCHEMBL19090262 | 1.00 | TSHR (0.55) | TSHRKCNA5KCNH2KCNE1CYP2D6 | |
| SCHEMBL8507855 | 0.88 | TSHR (0.57) | TSHRKCNA5KCNH2KCNE1CYP2D6 | |
| SCHEMBL65284 | 0.88 | TSHR (0.62) | TSHRKCNA5KCNH2KCNE1CYP2D6 | |
| SCHEMBL29520435 | 0.88 | TSHR (0.62) | TSHRKCNA5KCNH2KCNE1CYP2D6 | |
| SCHEMBL21510400 | 0.85 | TSHR (0.51) | TSHRKCNA5KCNH2KCNE1CYP2D6 | |
| SCHEMBL19090268 | 0.81 | TSHR (0.51) | TSHRKCNA5KCNH2KCNE1CYP2D6 | |
| SCHEMBL21999063 | 0.81 | TSHR (0.51) | TSHRKCNA5KCNH2KCNE1CYP2D6 | |
| 2-Aminopyridine SCHEMBL6249297 | 0.81 | NOS3 (0.57) | TSHRKCNA5KCNH2KCNE1CYP2D6 | |
| SCHEMBL19710412 | 0.81 | TSHR (0.51) | TSHRKCNA5KCNH2KCNE1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355695-A1 | SMYD Inhibitors | Epizyme, Inc. (US) | 2017-12-14 | — | — | US | disclosed |
| US-20170190676-A1 | Isoxazole Carboxamide Compounds | Epizyme, Inc. (US) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190676-A1 | Isoxazole Carboxamide Compounds | SMYD3, SMYD2, SNRPD3 | TSHR 3559/4885KCNA5 3663/4885KCNH2 3260/4885 |
| US-20170355695-A1 | SMYD Inhibitors | SMYD3, SMYD2, SMURF2 | TSHR 4530/4885KCNA5 3573/4885KCNH2 3261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.