Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.32 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19090761 | 0.82 | TSHR (0.56) | MAPK1TSHRSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL19079697 | 0.65 | TSHR (0.81) | MAPK1TSHRSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL19079803 | 0.61 | MAPK1 (0.34) | MAPK1TSHRSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL19079801 | 0.60 | TSHR (0.48) | MAPK1TSHRSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL9123882 | 0.56 | L3MBTL1 (0.46) | MAPK1SMN1; SMN2ALDH1A1MAPTTDP1 | |
| SCHEMBL6886932 | 0.55 | CYP1A2 (0.46) | MAPK1SMN1; SMN2MAPTTDP1PTPN7 | |
| SCHEMBL18288636 | 0.55 | L3MBTL1 (0.44) | SMN1; SMN2MAPTTDP1POLBL3MBTL1 | |
| SCHEMBL16438582 | 0.54 | POLB (0.48) | MAPK1TSHRSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL9122963 | 0.54 | L3MBTL1 (0.43) | MAPK1SMN1; SMN2ALDH1A1MAPTTDP1 | |
| SCHEMBL508614 | 0.53 | GAA (0.51) | SMN1; SMN2ALDH1A1KDM4EMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | VANDERBILT UNIVERSITY | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | PDE4A, PDE4B, PDE7A | MAPK1 916/4885TSHR 3082/4885SMN1; SMN2 4025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.