Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19079801 | 0.82 | TSHR (0.48) | MAPK1SMN1; SMN2TSHRHPGDTDP1 | |
| SCHEMBL11909359 | 0.59 | ATM (0.44) | SMN1; SMN2HSD17B10HPGDTDP1ALDH1A1 | |
| SCHEMBL6886932 | 0.58 | CYP1A2 (0.46) | MAPK1SMN1; SMN2PTPN7DUSP3HSD17B10 | |
| SCHEMBL24854624 | 0.56 | ATM (0.58) | SMN1; SMN2HSD17B10HPGDTDP1ALDH1A1 | |
| SCHEMBL1711871 | 0.56 | TDP1 (0.48) | SMN1; SMN2HSD17B10HPGDTDP1ALDH1A1 | |
| SCHEMBL13811346 | 0.56 | L3MBTL1 (0.55) | SMN1; SMN2TSHRTDP1POLBALDH1A1 | |
| SCHEMBL10195733 | 0.56 | KMT2A (0.57) | MAPK1TSHRTDP1POLBALDH1A1 | |
| SCHEMBL2379004 | 0.55 | GPR183 (0.56) | MAPK1SMN1; SMN2DUSP3TSHRHPGD | |
| SCHEMBL3141502 | 0.55 | FKBP1A (0.52) | SMN1; SMN2TSHRTDP1POLBLMNA | |
| SCHEMBL13621179 | 0.55 | ALDH1A1 (0.54) | SMN1; SMN2TSHRTDP1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | VANDERBILT UNIVERSITY | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | PDE4A, PDE4B, PDE7A | MAPK1 916/4885SMN1; SMN2 4025/4885PTPN7 2076/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.