Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 19/20 | 0.86 |
| ▸ | PRMT6 | Q96LA8 | 19/20 | 0.86 |
| ▸ | PRMT8 | Q9NR22 | 3/20 | 0.60 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.50 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20988126 | 0.88 | CARM1 (0.71) | CARM1PRMT6PRMT8TMEM97SIGMAR1 | |
| SCHEMBL19080588 | 0.87 | CARM1 (0.70) | CARM1PRMT6PRMT8TMEM97SIGMAR1 | |
| SCHEMBL12049739 | 0.81 | CARM1 (0.70) | CARM1PRMT6SIGMAR1SLC6A5 | |
| SCHEMBL7530604 | 0.79 | CARM1 (0.61) | CARM1PRMT6HRH3SLC6A5 | |
| SCHEMBL12041768 | 0.79 | CARM1 (0.68) | CARM1PRMT6PRMT8TMEM97SIGMAR1 | |
| SCHEMBL12041767 | 0.77 | CARM1 (0.65) | CARM1PRMT6PRMT8TMEM97SIGMAR1 | |
| SCHEMBL381729 | 0.76 | CARM1 (0.64) | CARM1PRMT6PRMT8TMEM97SIGMAR1 | |
| SCHEMBL22854624 | 0.76 | CARM1 (1.00) | CARM1PRMT6PRMT8TMEM97SIGMAR1 | |
| Lithium Ion SCHEMBL381730 | 0.75 | CARM1 (0.63) | CARM1PRMT6SLC6A5 | |
| SCHEMBL7529625 | 0.75 | CARM1 (0.56) | CARM1PRMT6HRH3SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10696707-B2 | Polyene macrolide derivative | SHIONOGI & CO., LTD. (JP) | 2020-06-30 | — | — | US | disclosed |
| US-20190135847-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2019-05-09 | — | — | US | disclosed |
| US-10246478-B2 | Polyene macrolide derivative | SHIONOGI & CO., LTD. (JP) | 2019-04-02 | — | — | US | disclosed |
| US-20170190729-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2017-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190729-A1 | POLYENE MACROLIDE DERIVATIVE | ERG28, RPL23, RPL10 | CARM1 4486/4885PRMT6 4274/4885PRMT8 4169/4885 |
| US-10246478-B2 | Polyene macrolide derivative | ERG28, RPL23, RPL10 | CARM1 4486/4885PRMT6 4274/4885PRMT8 4169/4885 |
| US-20190135847-A1 | POLYENE MACROLIDE DERIVATIVE | ERG28, RPL23, RPL10 | CARM1 4486/4885PRMT6 4274/4885PRMT8 4169/4885 |
| US-10696707-B2 | Polyene macrolide derivative | ERG28, RPL23, RPL10 | CARM1 4486/4885PRMT6 4274/4885PRMT8 4169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.