Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 11/20 | 0.42 |
| ▸ | NPC1 | O15118 | 10/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.41 |
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | MEN1 | O00255 | 9/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.40 |
| ▸ | RELA | Q04206 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL243858 | 0.79 | ALOX15 (0.44) | ALOX15RAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL243170 | 0.72 | ALOX15 (0.45) | ALOX15RAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL2028240 | 0.69 | ALOX15 (0.61) | ALOX15RAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL3373605 | 0.69 | SCD (0.55) | — | |
| SCHEMBL244247 | 0.67 | MEN1 (0.52) | RAB9ANPC1SMN1; SMN2HTTKMT2A | |
| SCHEMBL1976780 | 0.67 | ALOX15 (0.58) | ALOX15RAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL244336 | 0.67 | ALOX15 (0.58) | ALOX15RAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL26281541 | 0.67 | ALOX15 (0.58) | ALOX15RAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL243802 | 0.66 | ALOX15 (0.41) | ALOX15RAB9ANPC1SMN1; SMN2HTT | |
| SCHEMBL244462 | 0.66 | ALOX15 (0.41) | ALOX15RAB9ANPC1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293768-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-10-23 | — | — | US | disclosed |
| US-8293768-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-10-23 | — | — | US | disclosed |
| US-20120004164-A1 | ORGANIC COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2012-01-05 | — | — | US | disclosed |
| US-20120004164-A1 | ORGANIC COMPOUNDS | XENON PHARMACEUTICALS INC. (CA) | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120004164-A1 | ORGANIC COMPOUNDS | SCD, SCD5, FADS2 | ALOX15 110/4885RAB9A 4305/4885NPC1 228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.