Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.43 |
| ▸ | NOS1 | P29475 | 3/20 | 0.41 |
| ▸ | NOS2 | P35228 | 3/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CPS1 | P31327 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL190612 | 0.88 | GPR119 (0.44) | NOS1NOS2SYKNOS3 | |
| SCHEMBL190625 | 0.83 | GRM5 (0.51) | GRM5SYKTRPV4RAB9A | |
| SCHEMBL192005 | 0.81 | TRPV4 (0.47) | GRM5SYKTRPV4RAB9A | |
| Trifluoroacetic Acid SCHEMBL190215 | 0.81 | SYK (0.47) | GRM5SYKTRPV4GAA | |
| SCHEMBL190059 | 0.80 | CHEK2 (0.46) | GRM5SYKSMN1; SMN2 | |
| SCHEMBL20446212 | 0.80 | MAPK10 (0.53) | NOS1NOS2NOS3 | |
| SCHEMBL2658979 | 0.77 | TRPV4 (0.40) | GRM5SYKTRPV4SMN1; SMN2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL2461325 | 0.76 | ROCK1 (0.41) | GRM5SYKTRPV4 | |
| SCHEMBL192164 | 0.76 | ROCK1 (0.48) | GRM5TRPV4 | |
| SCHEMBL191226 | 0.75 | TRPV4 (0.43) | GRM5TRPV4SMN1; SMN2GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986645-B1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC (US) | 2012-01-04 | — | — | EP | disclosed |