Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.37 |
| ▸ | OGG1 | O15527 | 1/20 | 0.36 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.35 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3468550 | 0.86 | ESR1 (0.42) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL3467561 | 0.81 | ALOX15 (0.50) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL3468339 | 0.81 | ALOX15 (0.50) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL3468461 | 0.81 | ALOX15 (0.50) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL3468390 | 0.79 | ALOX15 (0.52) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL3468479 | 0.78 | ESR1 (0.38) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL3084800 | 0.78 | CHRM2 (0.47) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL3469110 | 0.76 | ALDH1A1 (0.44) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL3468437 | 0.76 | ESR1 (0.44) | ESR1PGRCHRM2ADORA3AR | |
| SCHEMBL3467959 | 0.75 | ESR1 (0.38) | ESR1PGRCHRM2ADORA3AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200331828-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | UNIV ILLINOIS (US) | 2020-10-22 | — | — | US | disclosed |
| US-20200331828-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | UNIV ILLINOIS (US) | 2020-10-22 | — | — | US | disclosed |
| US-10703698-B2 | Compounds which activate estrogen receptors and compositions and methods of using the same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2020-07-07 | — | — | US | disclosed |
| US-10703698-B2 | Compounds which activate estrogen receptors and compositions and methods of using the same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2020-07-07 | — | — | US | disclosed |
| US-20190002380-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2019-01-03 | — | — | US | disclosed |
| US-20190002380-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2019-01-03 | — | — | US | disclosed |
| EP-3400071-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | The Board of Trustees of the University of Illinois (US) | 2018-11-14 | — | — | EP | disclosed |
| WO-2017120507-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2017-07-13 | — | — | WO | disclosed |
| WO-2017120507-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2017-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10703698-B2 | Compounds which activate estrogen receptors and compositions and methods of using the same | GPER1, ESRRG, ESR2 | ESR1 4/4885PGR 9/4885CHRM2 822/4885 |
| US-20190002380-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | GPER1, ESRRG, ESR2 | ESR1 4/4885PGR 10/4885CHRM2 667/4885 |
| US-20200331828-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | GPER1, ESRRG, ESR2 | ESR1 4/4885PGR 10/4885CHRM2 667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.