Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 3/20 | 0.33 |
| ▸ | HRH1 | P35367 | 3/20 | 0.33 |
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18498621 | 0.85 | LMNA (0.56) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL29609549 | 0.82 | LMNA (0.54) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL3830737 | 0.78 | JAK1 (0.39) | POLBDPP4JAK1JAK2CHRNB2 | |
| SCHEMBL1633241 | 0.78 | LMNA (0.56) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL1542778 | 0.78 | LMNA (0.49) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL14034308 | 0.77 | LMNA (0.48) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL14034326 | 0.77 | LMNA (0.48) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL20605787 | 0.75 | SMN1; SMN2 (0.47) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL9596540 | 0.75 | LMNA (0.47) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL3652718 | 0.75 | LMNA (0.56) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3400228-A1 | FUSED QUADRACYCLIC COMPOUNDS, COMPOSITIONS AND USES THEREOF | Tabomedex Biosciences, LLC (US) | 2018-11-14 | — | — | EP | disclosed |
| WO-2017120164-A1 | FUSED QUADRACYCLIC COMPOUNDS, COMPOSITIONS AND USES THEREOF | Tabomedex Biosciences, LLC (US) | 2017-07-13 | — | — | WO | disclosed |