Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CDC25A | P30304 | 1/20 | 0.42 |
| ▸ | CDC25C | P30307 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PLEC | Q15149 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18947824 | 0.89 | KDM4E (0.47) | APPMAOBKDM4EALDH1A1MAPT | |
| SCHEMBL19274902 | 0.88 | ALDH1A1 (0.51) | APPMAOBKDM4EALDH1A1MAPT | |
| SCHEMBL18799655 | 0.85 | USP2 (0.57) | KDM4EALDH1A1USP2MEN1KMT2A | |
| SCHEMBL19101825 | 0.85 | ABCB1 (0.48) | APPMAOBKDM4EALDH1A1MAPT | |
| SCHEMBL14148863 | 0.83 | USP2 (0.60) | APPCDC25ACDC25CHPGDUSP2 | |
| SCHEMBL16808265 | 0.80 | ALDH1A1 (0.51) | APPMAOBKDM4EALDH1A1MAPT | |
| SCHEMBL14527723 | 0.77 | CYP1A2 (0.48) | APPMAOBKDM4EALDH1A1MAPT | |
| SCHEMBL13772009 | 0.76 | ABCB1 (0.52) | MAOBKDM4EALDH1A1MAPTNPC1 | |
| SCHEMBL12909311 | 0.76 | CYP1A2 (0.43) | APPMAOBKDM4EALDH1A1MAPT | |
| SCHEMBL18504843 | 0.75 | MAOB (0.49) | APPMAOBKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701715-B2 | Conformationally-constrained kinked endosomal-disrupting peptides | THE UNIVERSITY OF KANSAS (US) | 2017-07-11 | — | — | US | disclosed |