Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | STAT6 | P42226 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ADK | P55263 | 3/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18483539 | 1.00 | TP53 (0.50) | TP53HIF1ASTAT6ALDH1A1HTT | |
| SCHEMBL18484345 | 0.93 | ADK (0.53) | TP53HIF1ASTAT6ALDH1A1HTT | |
| SCHEMBL18483538 | 0.92 | TP53 (0.57) | TP53HIF1ASTAT6ALDH1A1HTT | |
| SCHEMBL31231548 | 0.86 | ALDH1A1 (0.57) | TP53HIF1ASTAT6ALDH1A1HTT | |
| SCHEMBL18488755 | 0.86 | ALDH1A1 (0.57) | TP53HIF1ASTAT6ALDH1A1HTT | |
| SCHEMBL31231549 | 0.86 | ALDH1A1 (0.57) | TP53HIF1ASTAT6ALDH1A1HTT | |
| SCHEMBL18483827 | 0.86 | ALDH1A1 (0.57) | TP53HIF1ASTAT6ALDH1A1HTT | |
| SCHEMBL18503328 | 0.86 | ALDH1A1 (0.57) | TP53HIF1ASTAT6ALDH1A1HTT | |
| SCHEMBL18483497 | 0.86 | ALDH1A1 (0.57) | TP53HIF1ASTAT6ALDH1A1HTT | |
| SCHEMBL19317789 | 0.86 | ALDH1A1 (0.57) | TP53HIF1ASTAT6ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701706-B2 | Pyrrolopyrimidine nucleosides and analogs thereof | CHIMERIX, INC. (US) | 2017-07-11 | — | — | US | disclosed |