Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 9/20 | 0.43 |
| ▸ | RARG | P13631 | 8/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | RARA | P10276 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17451857 | 1.00 | RARB (0.43) | RARBRARGKDM4EASIC3RARA | |
| SCHEMBL17451864 | 1.00 | RARB (0.43) | RARBRARGKDM4EASIC3RARA | |
| SCHEMBL17435683 | 1.00 | RARB (0.43) | RARBRARGKDM4EASIC3RARA | |
| SCHEMBL17435680 | 1.00 | RARB (0.43) | RARBRARGKDM4EASIC3RARA | |
| SCHEMBL13831071 | 0.86 | RARB (0.41) | RARBRARGRARACYP3A4TP53 | |
| SCHEMBL13739548 | 0.82 | RARB (0.39) | RARBRARGRARACYP3A4CYP26A1 | |
| SCHEMBL17435747 | 0.78 | BCL2L1 (0.40) | — | |
| SCHEMBL17435749 | 0.78 | BCL2L1 (0.40) | — | |
| SCHEMBL17451865 | 0.78 | BCL2L1 (0.40) | — | |
| SCHEMBL17451863 | 0.78 | BCL2L1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701622-B2 | Antibacterial agents | ACHAOGEN, INC. (US) | 2017-07-11 | — | — | US | disclosed |