Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
| ▸ | RPA1 | P27694 | 4/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.32 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17451863 | 1.00 | BCL2L1 (0.40) | BCL2L1GPR35TBXAS1CHRNA7RPA1 | |
| SCHEMBL17435749 | 1.00 | BCL2L1 (0.40) | BCL2L1GPR35TBXAS1CHRNA7RPA1 | |
| SCHEMBL17451865 | 1.00 | BCL2L1 (0.40) | BCL2L1GPR35TBXAS1CHRNA7RPA1 | |
| SCHEMBL17435386 | 0.78 | HDAC1 (0.36) | CHRNA7HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL17453182 | 0.78 | TAS1R3 (0.38) | CHRNA7HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL17451867 | 0.78 | TAS1R3 (0.38) | CHRNA7HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL17435552 | 0.78 | TAS1R3 (0.38) | CHRNA7HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL19102868 | 0.78 | TAS1R3 (0.38) | CHRNA7HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL17435508 | 0.78 | HDAC1 (0.36) | CHRNA7HDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL19102811 | 0.78 | TAS1R3 (0.38) | CHRNA7HDAC1HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170369426-A1 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. | 2017-12-28 | — | — | US | disclosed |
| US-9701622-B2 | Antibacterial agents | ACHAOGEN, INC. (US) | 2017-07-11 | — | — | US | disclosed |
| US-20160280639-A1 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. | 2016-09-29 | — | — | US | disclosed |
| US-9403758-B2 | Antibacterial agents | ACHAOGEN, INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-20160016895-A1 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. | 2016-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016895-A1 | ANTIBACTERIAL AGENTS | MRPL21, ABCB11, LSS | BCL2L1 769/4885GPR35 3155/4885TBXAS1 1416/4885 |
| US-20170369426-A1 | ANTIBACTERIAL AGENTS | MRPL21, ABCB11, LSS | BCL2L1 769/4885GPR35 3155/4885TBXAS1 1416/4885 |
| US-20160280639-A1 | ANTIBACTERIAL AGENTS | MRPL21, ABCB11, LSS | BCL2L1 769/4885GPR35 3155/4885TBXAS1 1416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.