Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 4/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.36 |
| ▸ | PADI3 | Q9ULW8 | 1/20 | 0.36 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.36 |
| ▸ | PADI2 | Q9Y2J8 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 4/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 4/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1711387 | 0.84 | KMO (0.54) | KMOPIM1PIM3PIM2KDM4E | |
| SCHEMBL319603 | 0.78 | CTSA (0.46) | HSD17B14KMOPDE4APDE4BPDE4C | |
| SCHEMBL319496 | 0.78 | MGAM (0.44) | PIM1PIM3PIM2TDP1KDM4E | |
| SCHEMBL1711474 | 0.76 | KMO (0.44) | KMOPIM1PIM3PIM2TDP1 | |
| SCHEMBL1712177 | 0.74 | PIM1 (0.44) | KMOPIM1PIM3PIM2TDP1 | |
| SCHEMBL1711234 | 0.72 | P4HTM (0.53) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL1725525 | 0.72 | KDM4E (0.46) | KMOPIM1PIM3PIM2TDP1 | |
| SCHEMBL1722822 | 0.71 | KMO (0.54) | HSD17B14KMOTDP1KDM4EALOX15 | |
| SCHEMBL1910596 | 0.71 | KDM4E (0.36) | PIM1PIM3PIM2TDP1KDM4E | |
| SCHEMBL1711956 | 0.71 | CTSA (0.50) | GRM2PIM1PIM3PIM2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |