Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 13/20 | 0.55 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.55 |
| ▸ | KDR | P35968 | 9/20 | 0.55 |
| ▸ | PRKAB1 | Q9Y478 | 8/20 | 0.55 |
| ▸ | ACVR1B | P36896 | 12/20 | 0.50 |
| ▸ | BMPR1B | O00238 | 11/20 | 0.50 |
| ▸ | ACVRL1 | P37023 | 11/20 | 0.50 |
| ▸ | BMPR1A | P36894 | 10/20 | 0.50 |
| ▸ | TGFBR2 | P37173 | 7/20 | 0.50 |
| ▸ | BMPR2 | Q13873 | 7/20 | 0.50 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | BMP4 | P12644 | 2/20 | 0.46 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | YES1 | P07947 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.46 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17448632 | 0.90 | ACVR1 (0.70) | ACVR1TGFBR1KDRPRKAB1ACVR1B | |
| SCHEMBL17441832 | 0.90 | ACVR1 (0.70) | ACVR1TGFBR1KDRPRKAB1ACVR1B | |
| SCHEMBL17441835 | 0.90 | ACVR1 (0.70) | ACVR1TGFBR1KDRPRKAB1ACVR1B | |
| SCHEMBL19110489 | 0.87 | ACVR1 (0.57) | ACVR1TGFBR1KDRPRKAB1ACVR1B | |
| SCHEMBL19110491 | 0.83 | ACVR1B (0.55) | ACVR1TGFBR1KDRPRKAB1ACVR1B | |
| SCHEMBL23988878 | 0.82 | KDR (0.64) | ACVR1TGFBR1KDRPRKAB1BMPR1B | |
| SCHEMBL17441824 | 0.82 | RET (0.50) | ACVR1TGFBR1KDRPRKAB1ACVR1B | |
| SCHEMBL17441825 | 0.82 | RET (0.50) | ACVR1TGFBR1KDRPRKAB1ACVR1B | |
| SCHEMBL26867134 | 0.81 | ACVR1 (0.69) | ACVR1TGFBR1KDRPRKAB1ACVR1B | |
| SCHEMBL19110487 | 0.81 | ACVR1 (0.62) | ACVR1TGFBR1KDRPRKAB1ACVR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170197968-A1 | Compositions and Methods for Inhibiting BMP | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170197968-A1 | Compositions and Methods for Inhibiting BMP | BMP1, BMP2, BMPR2 | ACVR1 12/4885TGFBR1 45/4885KDR 217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.