Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.68 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.68 |
| ▸ | CCR2 | P41597 | 3/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.55 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.54 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19112772 | 0.86 | TACR1 (0.58) | POLBALDH1A1TAS1R3TAS1R1CCR2 | |
| SCHEMBL18086864 | 0.84 | POLB (0.64) | POLBALDH1A1TAS1R3TAS1R1CCR2 | |
| SCHEMBL6360091 | 0.82 | POLB (1.00) | POLBALDH1A1TAS1R3TAS1R1NPSR1 | |
| SCHEMBL30739602 | 0.82 | POLB (0.78) | POLBALDH1A1TAS1R3TAS1R1NPSR1 | |
| SCHEMBL2855037 | 0.82 | POLB (0.78) | POLBALDH1A1TAS1R3TAS1R1NPSR1 | |
| SCHEMBL19113310 | 0.82 | TACR1 (0.50) | POLBALDH1A1TAS1R3TAS1R1CCR2 | |
| SCHEMBL19113183 | 0.82 | NOTUM (0.52) | POLBALDH1A1TAS1R3TAS1R1CCR2 | |
| SCHEMBL7674146 | 0.81 | POLB (0.64) | POLBALDH1A1TAS1R3TAS1R1CCR2 | |
| SCHEMBL7674144 | 0.81 | POLB (0.64) | POLBALDH1A1TAS1R3TAS1R1CCR2 | |
| SCHEMBL703500 | 0.81 | TAS1R3 (1.00) | POLBALDH1A1TAS1R3TAS1R1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189839-A1 | N-PIPERIDINYL ACETAMIDE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Taro Pharmaceuticals Inc. (CA) | 2017-07-12 | — | — | EP | disclosed |