Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 14/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL89994 | 1.00 | REN (0.41) | RENKCNH2MAPK1NR1H2KMT2A | |
| SCHEMBL90236 | 0.91 | REN (0.40) | RENKCNH2MAPK1NR1H2GAA | |
| SCHEMBL89416 | 0.90 | NR1H2 (0.41) | MAPK1NR1H2KMT2AGAAALOX15 | |
| SCHEMBL89070 | 0.87 | NR1H2 (0.41) | MAPK1NR1H2KMT2AGAAALOX15 | |
| SCHEMBL21641579 | 0.83 | NR1H2 (0.42) | NR1H2KMT2A | |
| SCHEMBL89314 | 0.81 | NR1H2 (0.40) | MAPK1NR1H2KMT2AGAAALOX15 | |
| SCHEMBL90387 | 0.78 | HSD17B10 (0.47) | NR1H2KMT2ASMN1; SMN2 | |
| SCHEMBL89075 | 0.78 | HSD17B10 (0.47) | NR1H2KMT2ASMN1; SMN2 | |
| SCHEMBL90735 | 0.78 | HSD17B10 (0.47) | NR1H2KMT2ASMN1; SMN2 | |
| SCHEMBL88882 | 0.78 | NR1H2 (0.41) | RENMAPK1NR1H2KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420491-A1 | 3 , 5-substitued piperidine compounds as renin inhibitors | Novartis AG (CH) | 2012-02-22 | — | — | EP | disclosed |