Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2233168 | 0.82 | ALDH1A1 (0.55) | ALDH1A1CYP1A2THRBMEN1POLB | |
| SCHEMBL9517032 | 0.82 | ALDH1A1 (0.55) | ALDH1A1CYP1A2THRBMEN1POLB | |
| SCHEMBL22821372 | 0.81 | ALDH1A1 (0.41) | ALDH1A1THRBTSHRBLMPMP22 | |
| SCHEMBL15965440 | 0.78 | ALDH1A1 (0.50) | ALDH1A1CYP1A2THRBMEN1POLB | |
| SCHEMBL11200987 | 0.78 | ALDH1A1 (0.50) | ALDH1A1CYP1A2THRBMEN1POLB | |
| SCHEMBL18052396 | 0.76 | CYP1A2 (0.34) | CYP1A2 | |
| SCHEMBL10965160 | 0.76 | ALDH1A1 (0.61) | ALDH1A1CYP1A2THRBMEN1POLB | |
| SCHEMBL21775830 | 0.76 | CYP1A2 (0.43) | ALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL1250798 | 0.75 | MEN1 (0.31) | MEN1POLBKMT2A | |
| SCHEMBL15965443 | 0.75 | ALDH1A1 (0.58) | ALDH1A1CYP1A2THRBMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017118700-A1 | CONTROLLED-RELEASE CNP AGONISTS WITH INCREASED NEP STABILITY | ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) | 2017-07-13 | — | — | WO | disclosed |
| WO-2017118698-A1 | CNP PRODRUGS WITH CARRIER ATTACHMENT AT THE RING MOIETY | ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) | 2017-07-13 | — | — | WO | disclosed |
| WO-2017118707-A1 | CONTROLLED-RELEASE CNP AGONISTS WITH REDUCED SIDE-EFFECTS | ASCENDIS PHARMA GROWTH DISORDERS A/S (DK) | 2017-07-13 | — | — | WO | disclosed |