Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.55 |
| ▸ | CA2 | P00918 | 4/20 | 0.55 |
| ▸ | CA12 | O43570 | 3/20 | 0.55 |
| ▸ | CA3 | P07451 | 3/20 | 0.55 |
| ▸ | CA4 | P22748 | 3/20 | 0.55 |
| ▸ | CA6 | P23280 | 3/20 | 0.55 |
| ▸ | CA5A | P35218 | 3/20 | 0.55 |
| ▸ | CA7 | P43166 | 3/20 | 0.55 |
| ▸ | CA9 | Q16790 | 3/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.55 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 3/20 | 0.55 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.55 |
| ▸ | DPP4 | P27487 | 2/20 | 0.55 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | TYR | P14679 | 1/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19116961 | 0.83 | TTR (0.52) | CA1CA2CA12CA3CA4 | |
| SCHEMBL19100834 | 0.83 | TTR (0.52) | CA1CA2CA12CA3CA4 | |
| SCHEMBL3453700 | 0.82 | CYP3A4 (0.74) | CA1CA2CA12CA3CA4 | |
| SCHEMBL3690722 | 0.82 | CYP3A4 (0.74) | CA1CA2CA12CA3CA4 | |
| SCHEMBL4946181 | 0.82 | HCAR2 (0.71) | CA1CA2CA12CA3CA4 | |
| SCHEMBL4946176 | 0.82 | HCAR2 (0.71) | CA1CA2CA12CA3CA4 | |
| SCHEMBL1510040 | 0.80 | FOS (0.59) | CA1CA2CA12CA3CA4 | |
| SCHEMBL11826245 | 0.80 | FOS (0.59) | CA1CA2CA12CA3CA4 | |
| SCHEMBL3293830 | 0.78 | ESR1 (0.88) | CA1CA2CA12CA3CA4 | |
| SCHEMBL3293835 | 0.78 | ESR1 (0.88) | CA1CA2CA12CA3CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200331828-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | UNIV ILLINOIS (US) | 2020-10-22 | — | — | US | disclosed |
| US-10703698-B2 | Compounds which activate estrogen receptors and compositions and methods of using the same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2020-07-07 | — | — | US | disclosed |
| US-20190002380-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2019-01-03 | — | — | US | disclosed |
| WO-2017120507-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2017-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10703698-B2 | Compounds which activate estrogen receptors and compositions and methods of using the same | GPER1, ESRRG, ESR2 | CA1 618/4885CA2 2016/4885CA12 1928/4885 |
| US-20190002380-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | GPER1, ESRRG, ESR2 | CA1 810/4885CA2 2607/4885CA12 1930/4885 |
| US-20200331828-A1 | NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME | GPER1, ESRRG, ESR2 | CA1 810/4885CA2 2607/4885CA12 1930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.