Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19118750 | 0.86 | KMT2A (0.37) | LMNASHMT2RAB9ANPC1KMT2A | |
| SCHEMBL352830 | 0.86 | SHMT2 (0.36) | LMNASHMT2RAB9ANPC1KMT2A | |
| SCHEMBL19119126 | 0.85 | LMNA (0.36) | LMNAROCK1SMN1; SMN2ROCK2MAPT | |
| SCHEMBL19119542 | 0.83 | ROCK1 (0.40) | LMNAROCK1ROCK2 | |
| SCHEMBL19119206 | 0.82 | LMNA (0.38) | LMNAROCK1SMN1; SMN2ROCK2MAPT | |
| SCHEMBL354220 | 0.76 | ROCK1 (0.38) | LMNAROCK1SMN1; SMN2ROCK2MAPT | |
| SCHEMBL352380 | 0.76 | ROCK1 (0.39) | LMNARAB9AROCK1ROCK2 | |
| SCHEMBL353678 | 0.75 | ROCK1 (0.36) | LMNAROCK1SMN1; SMN2ROCK2MAPT | |
| SCHEMBL19119502 | 0.74 | ROCK1 (0.35) | LMNARAB9ANPC1ROCK1SMN1; SMN2 | |
| SCHEMBL19119368 | 0.73 | KDM4E (0.36) | LMNASHMT2KMT2ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200440-B1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | CRESTONE INC (US) | 2017-07-19 | — | — | EP | claimed |