Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | BCAT2 | O15382 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL353718 | 0.88 | MAPT (0.45) | MAPTROCK2ATG4BROCK1THRB | |
| SCHEMBL19119383 | 0.84 | THRB (0.36) | MAPTTHRBLMNATP53BCAT2 | |
| SCHEMBL19119534 | 0.78 | ROCK2 (0.43) | MAPTROCK2ATG4BROCK1LMNA | |
| SCHEMBL19119260 | 0.78 | ROCK2 (0.42) | MAPTROCK2ATG4BROCK1NAMPT | |
| SCHEMBL19119139 | 0.78 | MAPK1 (0.44) | MAPTROCK2ATG4BROCK1LMNA | |
| SCHEMBL353549 | 0.77 | MAPT (0.45) | MAPTROCK2ATG4BROCK1THRB | |
| SCHEMBL19119229 | 0.76 | ROCK2 (0.42) | ROCK2ATG4BROCK1NAMPTMAPK1 | |
| SCHEMBL19118725 | 0.76 | ROCK2 (0.42) | MAPTROCK2ATG4BROCK1LMNA | |
| SCHEMBL19119544 | 0.76 | ROCK2 (0.42) | ROCK2ATG4BROCK1NAMPTMAPK1 | |
| SCHEMBL19118749 | 0.75 | ROCK2 (0.42) | MAPTROCK2ATG4BROCK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200440-B1 | ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS | CRESTONE INC (US) | 2017-07-19 | — | — | EP | claimed |