Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 4/20 | 0.75 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.69 |
| ▸ | INSR | P06213 | 3/20 | 0.69 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.64 |
| ▸ | EGFR | P00533 | 3/20 | 0.63 |
| ▸ | IGF1R | P08069 | 2/20 | 0.63 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.63 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.62 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.62 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.62 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.62 |
| ▸ | GSK3A | P49840 | 1/20 | 0.62 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.62 |
| ▸ | CDK2 | P24941 | 2/20 | 0.62 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.62 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.62 |
| ▸ | CDC7 | O00311 | 1/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.62 |
| ▸ | AURKA | O14965 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1912108 | 0.91 | ULK1 (0.64) | ULK1ALKINSRLRRK2EGFR | |
| SCHEMBL18650996 | 0.90 | ALK (0.85) | ALKINSRLRRK2EGFRIGF1R | |
| SCHEMBL31251193 | 0.87 | ALK (0.83) | ULK1ALKINSRLRRK2EGFR | |
| SCHEMBL375608 | 0.86 | ULK1 (1.00) | ULK1ALKINSRLRRK2EGFR | |
| SCHEMBL17547465 | 0.86 | ULK1 (1.00) | ULK1ALKINSRLRRK2EGFR | |
| SCHEMBL29900883 | 0.86 | ULK1 (1.00) | ULK1ALKINSRLRRK2EGFR | |
| SCHEMBL31174596 | 0.85 | ULK1 (0.87) | ULK1ALKINSRLRRK2EGFR | |
| SCHEMBL12312367 | 0.85 | ULK1 (0.81) | ULK1ALKINSRLRRK2EGFR | |
| SCHEMBL12780630 | 0.84 | ULK1 (0.65) | ULK1ALKINSRLRRK2EGFR | |
| SCHEMBL12780549 | 0.84 | ULK1 (0.84) | ULK1ALKINSRLRRK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660458-B1 | 2, 4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS | NOVARTIS AG (CH) | 2012-01-25 | — | — | EP | disclosed |
| EP-2287156-A1 | 2,4-Di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | Novartis AG (CH) | 2011-02-23 | — | — | EP | disclosed |