Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 6/20 | 0.39 |
| ▸ | SRC | P12931 | 6/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19121105 | 0.91 | EGFR (0.42) | EGFRERBB2ERBB4ABCG2FYN | |
| SCHEMBL19120555 | 0.85 | EGFR (0.38) | EGFRERBB2ERBB4ABCG2PIK3CD | |
| SCHEMBL12225352 | 0.77 | CLK4 (0.60) | EGFRERBB2ERBB4ABCG2FYN | |
| SCHEMBL19121096 | 0.76 | EGFR (0.42) | EGFRERBB2PIK3CDKDM4E | |
| SCHEMBL19121686 | 0.75 | FYN (0.35) | EGFRERBB2ERBB4ABCG2FYN | |
| SCHEMBL18387506 | 0.71 | EGFR (0.46) | EGFRERBB2FYNSRC | |
| SCHEMBL3707168 | 0.67 | EGFR (0.47) | EGFRERBB2ERBB4ABCG2 | |
| SCHEMBL24353219 | 0.67 | EGFR (0.55) | EGFR | |
| SCHEMBL12225357 | 0.64 | EGFR (0.61) | EGFRERBB2ERBB4 | |
| SCHEMBL22338293 | 0.64 | SRC (0.56) | EGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951051-B2 | Process for producing alkynylketone derivative | SHIONOGI & CO., LTD. (JP) | 2018-04-24 | — | — | US | disclosed |
| US-20170197943-A1 | PROCESS FOR PRODUCING ALKYNYLKETONE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2017-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170197943-A1 | PROCESS FOR PRODUCING ALKYNYLKETONE DERIVATIVE | PDK4, PDK3, PDK2 | EGFR 650/4885ERBB2 458/4885ERBB4 675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.