Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 7/20 | 0.58 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.58 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.57 |
| ▸ | CTSK | P43235 | 2/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.49 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.49 |
| ▸ | ITGAV | P06756 | 2/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | TACR2 | P21452 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17444424 | 1.00 | ITGB3 (0.58) | ITGB3ITGA2BSIRT2SIRT1CTSK | |
| SCHEMBL27122575 | 0.93 | ITGB3 (0.55) | ITGB3ITGA2BSIRT2SIRT1CTSK | |
| SCHEMBL26966086 | 0.93 | ITGB3 (0.55) | ITGB3ITGA2BSIRT2SIRT1CTSK | |
| SCHEMBL17444420 | 0.91 | SIRT2 (0.58) | ITGB3ITGA2BSIRT2SIRT1CTSK | |
| SCHEMBL17444419 | 0.91 | SIRT2 (0.58) | ITGB3ITGA2BSIRT2SIRT1CTSK | |
| SCHEMBL27273354 | 0.86 | SIRT2 (0.54) | ITGB3ITGA2BSIRT2SIRT1CTSK | |
| SCHEMBL5967157 | 0.86 | HRH1 (0.59) | ITGB3ITGA2BSIRT2SIRT1CTSK | |
| SCHEMBL17448220 | 0.84 | SIRT2 (0.54) | ITGB3ITGA2BSIRT2SIRT1CTSK | |
| SCHEMBL21994627 | 0.82 | ITGB3 (0.53) | ITGB3ITGA2BSIRT2SIRT1CTSK | |
| SCHEMBL19125526 | 0.82 | ITGB3 (0.66) | ITGB3ITGA2BITGAVMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3169368-B1 | LINKERS AND THEIR APPLICATION TOWARDS ADC | MEDSHINE DISCOVERY INC (CN) | 2021-02-17 | — | — | EP | disclosed |
| CN-107427591-B | Linker and its application to ADC | 南京明德新药研发股份有限公司 | 2020-12-29 | — | — | CN | disclosed |
| US-10280229-B2 | Linkers and their application towards ADC | MEDSHINE DISCOVERY INC. (CN) | 2019-05-07 | — | — | US | disclosed |
| US-20170202974-A1 | LINKERS AND THEIR APPLICATION TOWARDS ADC | MEDSHINE DISCOVERY INC. (CN) | 2017-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170202974-A1 | LINKERS AND THEIR APPLICATION TOWARDS ADC | DNPEP, DPP7, DPP3 | ITGB3 2572/4885ITGA2B 2246/4885SIRT2 711/4885 |
| US-10280229-B2 | Linkers and their application towards ADC | DNPEP, DPP7, DPP3 | ITGB3 2572/4885ITGA2B 2246/4885SIRT2 711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.