Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 6/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26966086 | 1.00 | ITGB3 (0.55) | ITGB3ITGA2BSIRT2SIRT1MEN1 | |
| SCHEMBL17444424 | 0.93 | ITGB3 (0.58) | ITGB3ITGA2BSIRT2SIRT1MEN1 | |
| SCHEMBL19125083 | 0.93 | ITGB3 (0.58) | ITGB3ITGA2BSIRT2SIRT1MEN1 | |
| SCHEMBL27273354 | 0.93 | SIRT2 (0.54) | ITGB3ITGA2BSIRT2SIRT1MEN1 | |
| SCHEMBL5967157 | 0.88 | HRH1 (0.59) | ITGB3ITGA2BSIRT2SIRT1MEN1 | |
| SCHEMBL17444419 | 0.84 | SIRT2 (0.58) | ITGB3ITGA2BSIRT2SIRT1CTSL | |
| SCHEMBL17444420 | 0.84 | SIRT2 (0.58) | ITGB3ITGA2BSIRT2SIRT1CTSL | |
| SCHEMBL19125526 | 0.84 | ITGB3 (0.66) | ITGB3ITGA2BMEN1KMT2ANPSR1 | |
| SCHEMBL12447237 | 0.83 | MEN1 (0.52) | SIRT2SIRT1MEN1KMT2ANPSR1 | |
| SCHEMBL7284529 | 0.83 | ALDH1A1 (0.60) | ITGB3ITGA2BMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230406885-A1 | CYCLIC PEPTIDES FOR TRAPPING INTERLEUKIN-1 BETA | MERCK SHARP & DOHME LLC (US) | 2023-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230406885-A1 | CYCLIC PEPTIDES FOR TRAPPING INTERLEUKIN-1 BETA | IL1A, IL1B, IL1R1 | ITGB3 1465/4885ITGA2B 869/4885SIRT2 2355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.