Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | GABRP | O00591 | 3/20 | 0.45 |
| ▸ | GABRD | O14764 | 3/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.45 |
| ▸ | GABRE | P78334 | 3/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.45 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.45 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.45 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.45 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191213 | 0.78 | DPP4 (0.40) | SMN1; SMN2DPP4L3MBTL1KMT2ATDP1 | |
| SCHEMBL1913153 | 0.77 | NOS3 (0.57) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL22538123 | 0.77 | KMT2A (0.42) | SMN1; SMN2DPP4KMT2ATDP1PKM | |
| SCHEMBL14431564 | 0.73 | SMN1; SMN2 (0.48) | SMN1; SMN2DPP4L3MBTL1KMT2APKM | |
| SCHEMBL14999835 | 0.73 | KMT2A (0.40) | SMN1; SMN2DPP4KMT2ATDP1PKM | |
| SCHEMBL21855464 | 0.73 | PKM (0.41) | SMN1; SMN2DPP4KMT2ATDP1PKM | |
| SCHEMBL19874265 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2DPP4KMT2AMAPK1ALDH1A1 | |
| SCHEMBL24614557 | 0.72 | SMN1; SMN2 (0.53) | SMN1; SMN2DPP4L3MBTL1KMT2AMAPK1 | |
| SCHEMBL21352047 | 0.72 | KMT2A (0.40) | SMN1; SMN2KMT2ATDP1PKMALDH1A1 | |
| SCHEMBL973326 | 0.72 | SMN1; SMN2 (0.39) | SMN1; SMN2DPP4KMT2ATDP1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986645-B1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC (US) | 2012-01-04 | — | — | EP | disclosed |
| US-8022222-B2 | Glucokinase activators | ARRAY BIOPHARMA, INC. (US) | 2011-09-20 | — | — | US | disclosed |
| US-20090247526-A1 | GLUCOKINASE ACTIVATORS | ARRAY BIOPHARMA INC. (US) | 2009-10-01 | — | — | US | disclosed |
| CN-101437512-A | Glucokinase activators | ARRAY BIOPHARMA INC (US) | 2009-05-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247526-A1 | GLUCOKINASE ACTIVATORS | GCKR, GCK, GALK1 | SMN1; SMN2 2600/4885GABRP 2134/4885GABRD 1931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.