Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.53 |
| ▸ | TGM2 | P21980 | 1/20 | 0.52 |
| ▸ | FPR2 | P25090 | 4/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.50 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.42 |
| ▸ | NPY4R | P50391 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL18617 | 0.92 | MEN1 (0.60) | MEN1BLMKMT2AUSP2POLB | |
| Hydrochloric Acid SCHEMBL29354092 | 0.92 | MEN1 (0.60) | MEN1BLMKMT2AUSP2POLB | |
| Hydrochloric Acid SCHEMBL30207638 | 0.92 | MEN1 (0.60) | MEN1BLMKMT2AUSP2POLB | |
| Hydrochloric Acid SCHEMBL10325011 | 0.91 | MEN1 (0.59) | MEN1BLMKMT2AUSP2POLB | |
| Hydrochloric Acid SCHEMBL31337069 | 0.91 | MEN1 (0.59) | MEN1BLMKMT2AUSP2POLB | |
| SCHEMBL3903552 | 0.91 | MEN1 (0.61) | MEN1BLMKMT2AUSP2POLB | |
| SCHEMBL29593395 | 0.91 | MEN1 (0.61) | MEN1BLMKMT2AUSP2POLB | |
| Stearic Acid SCHEMBL10583270 | 0.91 | TGM2 (0.55) | MEN1BLMKMT2AUSP2POLB | |
| Acetic Acid SCHEMBL29510237 | 0.88 | MEN1 (0.60) | MEN1BLMKMT2AUSP2POLB | |
| Perchlorate SCHEMBL31688153 | 0.88 | MEN1 (0.60) | MEN1BLMKMT2AUSP2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190017987-A1 | PERFORMING ONE OR MORE ANALYSES ON A THIN LAYER OF BIOLOGIC FLUID USING OPTICALLY RESPONSIVE CHEMICAL SENSORS | LEVINE ROBERT A (US) | 2019-01-17 | — | — | US | disclosed |
| WO-2017123296-A1 | PERFORMING ONE OR MORE ANALYSES ON A THIN LAYER OF BIOLOGIC FLUID USING OPTICALLY RESPONSIVE CHEMICAL SENSORS | LEVINE ROBERT A (US) | 2017-07-20 | — | — | WO | disclosed |