Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.46 |
| ▸ | CXCR3 | P49682 | 17/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1912900 | 1.00 | C5AR1 (0.46) | C5AR1CXCR3KCNH2CNR2 | |
| SCHEMBL5134524 | 1.00 | C5AR1 (0.46) | C5AR1CXCR3KCNH2CNR2 | |
| SCHEMBL649760 | 0.91 | C5AR1 (0.47) | C5AR1CXCR3 | |
| SCHEMBL648056 | 0.91 | C5AR1 (0.47) | C5AR1CXCR3 | |
| SCHEMBL648933 | 0.89 | C5AR1 (0.59) | C5AR1CXCR3 | |
| SCHEMBL1912894 | 0.89 | C5AR1 (0.59) | C5AR1CXCR3 | |
| SCHEMBL1912901 | 0.87 | C5AR1 (0.60) | C5AR1CXCR3KCNH2 | |
| SCHEMBL1912903 | 0.87 | C5AR1 (0.60) | C5AR1CXCR3KCNH2 | |
| SCHEMBL1912906 | 0.83 | C5AR1 (0.39) | C5AR1CXCR3 | |
| SCHEMBL1912904 | 0.83 | C5AR1 (0.39) | C5AR1CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |