Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.57 |
| ▸ | TACR1 | P25103 | 17/20 | 0.56 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.49 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.49 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8873238 | 0.85 | TACR1 (0.54) | IDO1TACR1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL20905132 | 0.85 | TACR1 (0.54) | IDO1TACR1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL20980896 | 0.84 | TACR1 (0.44) | IDO1TACR1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL20905201 | 0.83 | TACR1 (0.52) | IDO1TACR1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL10819598 | 0.82 | IDO1 (0.62) | IDO1TACR1HTR2AHTR2CHTR2B | |
| SCHEMBL22022403 | 0.82 | HMGCR (0.49) | IDO1TACR1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL20905117 | 0.80 | TACR1 (0.50) | IDO1TACR1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL12964410 | 0.80 | IDO1 (0.57) | IDO1TACR1 | |
| SCHEMBL9317434 | 0.78 | TACR1 (0.70) | TACR1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL4964961 | 0.78 | PTPN1 (0.34) | IDO1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11242331-B2 | Analogs of yohimbine and uses thereof | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2022-02-08 | — | — | US | disclosed |
| US-10807951-B2 | mTORC1 modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-10-20 | — | — | US | disclosed |
| US-20190256490-A1 | ANALOGS OF YOHIMBINE AND USES THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2019-08-22 | — | — | US | disclosed |
| WO-2019075386-A1 | MTORC1 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2019-04-18 | — | — | WO | disclosed |
| US-20190112268-A1 | mTORC1 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-04-18 | — | — | US | disclosed |
| US-20170204086-A1 | ALPHA-HELIX ANALOG HAVING TRIAZINE-PIPERAZINE BACKBONE AND METHOD FOR PREPARING SAME | POSTECH ACADEMY-INDUSTRY FOUNDATION (KR) | 2017-07-20 | — | — | US | disclosed |
| US-20170204086-A1 | ALPHA-HELIX ANALOG HAVING TRIAZINE-PIPERAZINE BACKBONE AND METHOD FOR PREPARING SAME | POSTECH ACADEMY-INDUSTRY FOUNDATION (KR) | 2017-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170204086-A1 | ALPHA-HELIX ANALOG HAVING TRIAZINE-PIPERAZINE BACKBONE AND METHOD FOR PREPARING SAME | HSPH1, HBZ, PITHD1 | IDO1 3581/4885TACR1 4286/4885CACNA1F 4657/4885 |
| US-11242331-B2 | Analogs of yohimbine and uses thereof | MAOA, MAOB, NPY5R | IDO1 44/4885TACR1 581/4885CACNA1F 1231/4885 |
| US-20190112268-A1 | mTORC1 MODULATORS | MTOR, RPTOR, RICTOR | IDO1 3976/4885TACR1 4699/4885CACNA1F 3703/4885 |
| US-20190256490-A1 | ANALOGS OF YOHIMBINE AND USES THEREOF | MAOA, MAOB, NPY5R | IDO1 44/4885TACR1 581/4885CACNA1F 1231/4885 |
| US-10807951-B2 | mTORC1 modulators | MTOR, RPTOR, RICTOR | IDO1 3976/4885TACR1 4699/4885CACNA1F 3703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.