Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.35 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19128783 | 0.89 | PSMB8 (0.41) | RORCDPP4PSMB8PSMB9PSMB5 | |
| SCHEMBL19132795 | 0.83 | RORC (0.52) | RORCDPP4PSMB8PSMB9PSMB5 | |
| SCHEMBL19132857 | 0.83 | RORC (0.47) | RORCDPP4PSMB8PSMB9PSMB5 | |
| SCHEMBL19132799 | 0.82 | RORC (0.43) | RORCDPP4PSMB8PSMB9PSMB5 | |
| SCHEMBL19128945 | 0.82 | PSMB8 (0.40) | RORCDPP4PSMB8PSMB9PSMB5 | |
| SCHEMBL19128917 | 0.77 | RORC (0.49) | RORCDPP4PSMB8PSMB9PSMB5 | |
| SCHEMBL19129023 | 0.74 | ROCK2 (0.45) | RORCPSMB8PSMB9PSMB5SMN1; SMN2 | |
| SCHEMBL19128796 | 0.72 | RORC (0.41) | RORCDPP4PSMB8PSMB9PSMB5 | |
| SCHEMBL19132705 | 0.71 | RORC (0.54) | RORCPSMB8PSMB9PSMB5SMN1; SMN2 | |
| SCHEMBL19128785 | 0.69 | RORC (0.53) | RORCALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708253-B2 | Cyclohexyl sulfone RORγ modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-07-18 | — | — | US | disclosed |