Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | CASP4 | P49662 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CASP9 | P55211 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19138449 | 0.84 | ALPL (0.46) | ALPLALDH1A1MAPK1HTTCYP1A2 | |
| SCHEMBL19138461 | 0.82 | ALPL (0.47) | ALPLALDH1A1MAPK1HTTCYP1A2 | |
| SCHEMBL19138408 | 0.81 | ALPL (0.51) | ALPLALDH1A1MAPK1HTT | |
| SCHEMBL19138492 | 0.79 | ALPL (0.47) | ALPLALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL19138410 | 0.78 | ALPL (0.47) | ALPLLRRK2 | |
| SCHEMBL19138462 | 0.77 | ALPL (0.49) | ALPLALDH1A1CYP1A2CYP2C9HPGD | |
| SCHEMBL19138457 | 0.77 | ALPL (0.46) | ALPLALDH1A1MAPK1HTTCASP1 | |
| SCHEMBL19138439 | 0.77 | ALPL (0.46) | ALPLALDH1A1MAPK1HTTCASP1 | |
| SCHEMBL19138484 | 0.77 | ALPL (0.46) | ALPLALDH1A1MAPK1HTTCASP1 | |
| SCHEMBL19138429 | 0.77 | ALPL (0.46) | ALPLALDH1A1MAPK1HTTCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3319970-B1 | PYRIDO-OXAZINONE DERIVATIVES AS TNAP INHIBITORS | DAIICHI SANKYO CO LTD (JP) | 2019-08-28 | — | — | EP | disclosed |
| US-10221195-B2 | Pyridine compounds | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-03-05 | — | — | US | disclosed |
| US-20180141960-A1 | PYRIDINE COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-05-24 | — | — | US | disclosed |
| US-9920068-B2 | Pyridine compounds | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-03-20 | — | — | US | disclosed |
| US-9879032-B2 | Pyridine compounds | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2018-01-30 | — | — | US | disclosed |
| US-20170240562-A1 | PYRIDINE COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-08-24 | — | — | US | disclosed |
| US-20170210755-A1 | PYRIDINE COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2017-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141960-A1 | PYRIDINE COMPOUNDS | ALPI, ALPP, ALPL | ALPL 3/4885ALDH1A1 168/4885MAPK1 606/4885 |
| US-20170240562-A1 | PYRIDINE COMPOUNDS | ALPI, ALPP, ALPL | ALPL 3/4885ALDH1A1 168/4885MAPK1 606/4885 |
| US-10221195-B2 | Pyridine compounds | ALPI, ALPP, ALPL | ALPL 3/4885ALDH1A1 168/4885MAPK1 606/4885 |
| US-20170210755-A1 | PYRIDINE COMPOUNDS | ALPI, ALPP, ALPL | ALPL 3/4885ALDH1A1 168/4885MAPK1 606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.