SCHEMBL1914065

SCHEMBL1914065

Cc1nc([C@@]2(C(C)(C)C)CCCN2C(=O)O)[nH]c1I

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 2/20 0.32
HCRTR2 O43614 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1914704 0.88 HCRTR1 (0.31) HCRTR1HCRTR2
SCHEMBL1914123 0.79 KDM5A (0.31)
SCHEMBL934566 0.77 HCRTR1 (0.37) HCRTR1HCRTR2
SCHEMBL1914340 0.77 HCRTR1 (0.32) HCRTR1HCRTR2
SCHEMBL23247405 0.76 HCRTR1 (0.33) HCRTR1HCRTR2
SCHEMBL1984447 0.73 HCRTR1 (0.33) HCRTR1HCRTR2
SCHEMBL1984448 0.73 HCRTR1 (0.33) HCRTR1HCRTR2
SCHEMBL1914368 0.73 JAK3 (0.33)
SCHEMBL17938124 0.72 ALDH1A1 (0.42) HCRTR1HCRTR2
SCHEMBL17938125 0.72 ALDH1A1 (0.42) HCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011079327-A1 ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS VERTEX PHARMACEUTICALS INCORPORATED (US) 2011-06-30 WO disclosed