Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.69 |
| ▸ | PARP1 | P09874 | 5/20 | 0.69 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.50 |
| ▸ | METAP1 | P53582 | 2/20 | 0.43 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31585995 | 0.81 | PARP10 (1.00) | PARP10PARP1PARP11F7F3 | |
| SCHEMBL2619126 | 0.81 | PARP10 (1.00) | PARP10PARP1PARP11F7F3 | |
| SCHEMBL13090790 | 0.81 | PARP10 (0.49) | PARP10PARP1PARP11METAP1CYP19A1 | |
| SCHEMBL16369423 | 0.77 | GFER (0.44) | PARP10PARP1PARP11F7F3 | |
| SCHEMBL15850581 | 0.75 | PARP10 (0.41) | PARP10PARP1PARP11F7F3 | |
| SCHEMBL1159918 | 0.72 | PARP10 (0.59) | PARP10PARP1PARP11F7F3 | |
| SCHEMBL426519 | 0.72 | PARP10 (0.56) | PARP10PARP1PARP11GRM5 | |
| SCHEMBL30564582 | 0.72 | PARP10 (0.56) | PARP10PARP1PARP11GRM5 | |
| SCHEMBL15830755 | 0.71 | PARP10 (0.81) | PARP10PARP1PARP11METAP1F7 | |
| Hydrochloric Acid SCHEMBL549603 | 0.71 | PARP10 (0.55) | PARP10PARP1PARP11GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024039883-A2 | COMPOSITIONS AND METHODS TO TREAT MYELOPROLIFERATIVE DISORDERS AND MYELOPROLIFERATIVE NEOPLASMS | TRANSLATIONAL DRUG DEVELOPMENT LLC (US) | 2024-02-22 | — | — | WO | disclosed |
| EP-2046799-B1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GENENTECH INC (US) | 2017-07-19 | — | — | EP | disclosed |