SCHEMBL426519

SCHEMBL426519

Cc1ccc2c(c1)NCC2

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 3/20 0.56
PARP1 P09874 1/20 0.56
PARP11 Q9NR21 2/20 0.52
ALDH1A1 P00352 3/20 0.48
MAPT P10636 3/20 0.48
GAA P10253 1/20 0.48
HSD17B10 Q99714 1/20 0.48
GFER P55789 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
DRD2 P14416 1/20 0.44
DRD4 P21917 1/20 0.44
HTR5A P47898 2/20 0.42
KDM4E B2RXH2 1/20 0.37
LMNA P02545 1/20 0.37
GRM5 P41594 1/20 0.36
S1PR1 P21453 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30564582 1.00 PARP10 (0.56) PARP10PARP1PARP11ALDH1A1MAPT
Hydrochloric Acid SCHEMBL549603 0.98 PARP10 (0.55) PARP10PARP1PARP11ALDH1A1MAPT
SCHEMBL3111834 0.88 MAPT (0.50) PARP10PARP1PARP11ALDH1A1MAPT
SCHEMBL30634161 0.88 MAPT (0.50) PARP10PARP1PARP11ALDH1A1MAPT
SCHEMBL5467021 0.86 MAPT (0.49) PARP10PARP1PARP11ALDH1A1MAPT
SCHEMBL12461 0.83 DRD2 (0.59) PARP10PARP1PARP11ALDH1A1MAPT
SCHEMBL15601745 0.81 PARP10 (0.56) PARP10PARP1PARP11ALDH1A1MAPT
SCHEMBL9055504 0.78 ALDH1A1 (0.44) PARP10PARP1PARP11ALDH1A1MAPT
SCHEMBL16602943 0.77
SCHEMBL6966954 0.77 HTR5A (0.53) PARP10PARP1PARP11ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 418 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10224485-B2 Process for preparing a crystalline organic semiconductor material BASF SE (DE) 2019-03-05 US claimed
CN-116145156-B Indoline compound preparation method based on organic electronic synthesis 六盘水师范学院 2026-05-15 CN disclosed
US-20260125367-A1 CANCER TREATMENTS TARGETING CANCER STEM CELLS REMEDY PLAN, INC. (US) 2026-05-07 US disclosed
US-20260092051-A1 PYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING CANCERS INCLUDING THE SAME HANMI PHARMACEUTICAL CO LTD (KR) 2026-04-02 US disclosed
US-12522587-B2 Cancer treatments targeting cancer stem cells REMEDY PLAN, INC. (US) 2026-01-13 US disclosed
EP-4605089-A1 COMPOUNDS USEFUL IN MODULATING EGFR AND PI3K Mekanistic Therapeutics LLC (US) 2025-08-27 EP disclosed
US-12325698-B2 Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same HANMI PHARM. CO., LTD. (KR) 2025-06-10 US disclosed
US-20250171420-A1 MOLECULAR GLUE DEGRADERS AND METHODS OF USING THE SAME MONTE ROSA THERAPEUTICS AG (CH) 2025-05-29 US disclosed
EP-4540240-A1 MOLECULAR GLUE DEGRADERS AND METHODS OF USING THE SAME Monte Rosa Therapeutics AG (CH) 2025-04-23 EP disclosed
CN-119822910-A Method for catalyzing heterogeneous reduction of nitrogen-containing heterocyclic compound by using magnesium metal 延安大学 2025-04-15 CN disclosed
EP-0888349-A1 PYRROLOPYRIMIDINES AND PROCESSES FOR THEIR PREPARATION Novartis AG (CH) 1999-01-07 EP disclosed
US-5773618-A PYRROLOQUINOLINONE DERIVATIVES SANKYO COMPANY, LIMITED (JP) 1998-06-30 US disclosed
US-5736534-A HYPERPROLIFERATIVE DISEASES; INHIBITORS OF PROTEIN-TYROSINE KINASES SUCH AS EPIDERMAL GROWTH FACTOR RECEPTOR; BRAIN, LUNG, BREAST CANCER; PSORIASIS AND BENIGN PROSTATE HYPERPLASIA PFIZER INC. (US) 1998-04-07 US disclosed
CN-1172809-A Tricyclic compounds having fungicidal activity, their preparation and their use SANKYO CO (JP) 1998-02-11 CN disclosed
EP-0807631-A1 Tricyclic compounds having fungicidal activity, their preparation and their use SANKYO COMPANY LIMITED (JP) 1997-11-19 EP disclosed
WO-1997027199-A1 PYRROLOPYRIMIDINES AND PROCESSES FOR THEIR PREPARATION NOVARTIS AG (CH) 1997-07-31 WO disclosed
CN-1141633-A 4-heterocyclic substituted quinazoline derivatives, process for their preparation and their use as anticancer agents PFIZER (US) 1997-01-29 CN disclosed
EP-0746554-A1 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS PFIZER INC. (US) 1996-12-11 EP disclosed
WO-1995023141-A1 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS PFIZER INC. (US) 1995-08-31 WO disclosed
US-4186199-A Indolo-,1,2-dihydroindolo-, and 1,2,6,7-tetrahydroindolo [1,7-ab][1,5] benzodiazepines AMERICAN HOECHST CORPORATION (US) 1980-01-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12325698-B2 Pyrimidine compounds and pharmaceutical compositions for preventing or treating cancers including the same DPYD, TYMS, TYMP PARP10 901/4885PARP1 122/4885PARP11 400/4885
US-20260125367-A1 CANCER TREATMENTS TARGETING CANCER STEM CELLS MCL1, MALT1, BCL6 PARP10 3986/4885PARP1 474/4885PARP11 842/4885
US-20250171420-A1 MOLECULAR GLUE DEGRADERS AND METHODS OF USING THE SAME PSMA1, CSNK1G1, CSNK1A1 PARP10 705/4885PARP1 307/4885PARP11 319/4885
US-10224485-B2 Process for preparing a crystalline organic semiconductor material STOM, SPOP, TTR PARP10 4841/4885PARP1 4793/4885PARP11 4883/4885
US-20260092051-A1 PYRIMIDINE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING CANCERS INCLUDING THE SAME FLT3, FLT1, ADK PARP10 1055/4885PARP1 638/4885PARP11 468/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.