Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 5/20 | 0.46 |
| ▸ | BCL2 | P10415 | 6/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20082221 | 0.89 | PTGS2 (0.40) | BCL2L1BCL2PTGS2PTGS1HRH3 | |
| SCHEMBL10058349 | 0.84 | BCL2L1 (0.50) | BCL2L1BCL2PTGS2PTGS1 | |
| SCHEMBL1677751 | 0.82 | BCL2L1 (0.49) | BCL2L1BCL2PTGS2PTGS1 | |
| SCHEMBL25215204 | 0.82 | BCL2L1 (0.51) | BCL2L1BCL2PTGS2PTGS1 | |
| SCHEMBL1113744 | 0.80 | BCL2L1 (0.52) | BCL2L1BCL2PTGS2PTGS1ACHE | |
| SCHEMBL18011819 | 0.80 | BCL2L1 (0.49) | BCL2L1BCL2PTGS2PTGS1 | |
| SCHEMBL24917425 | 0.78 | PTGS1 (0.39) | BCL2L1BCL2PTGS2PTGS1HRH3 | |
| SCHEMBL19867722 | 0.78 | PTGS1 (0.34) | BCL2L1BCL2PTGS2PTGS1ACHE | |
| SCHEMBL22566773 | 0.76 | BCL2L1 (0.44) | BCL2L1BCL2PTGS2PTGS1 | |
| SCHEMBL25935815 | 0.76 | PTGS2 (0.38) | PTGS2PTGS1HRH3MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017123616-A1 | INHIBITING B-CELL LYMPHOMA 2 (BCL-2) AND RELATED PROTEINS | MERRIMACK PHARMACEUTICALS, INC. (US) | 2017-07-20 | — | — | WO | disclosed |