Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19147639 | 0.85 | GPR119 (0.62) | GPR119ALDH1A1NPBWR1MCHR1PDE4A | |
| SCHEMBL2538047 | 0.84 | GPR119 (0.53) | GPR119NPBWR1MCHR1 | |
| SCHEMBL4469107 | 0.84 | GPR119 (0.53) | GPR119NPBWR1MCHR1 | |
| SCHEMBL2774428 | 0.84 | GPR119 (0.53) | GPR119NPBWR1MCHR1 | |
| SCHEMBL19764131 | 0.83 | GPR119 (0.53) | GPR119NPBWR1MCHR1PTPN2PTPN1 | |
| SCHEMBL3343105 | 0.83 | GPR119 (0.52) | GPR119NPBWR1MCHR1PDE4APDE4B | |
| SCHEMBL20303652 | 0.83 | GPR119 (0.52) | GPR119NPBWR1MCHR1PDE4APDE4B | |
| SCHEMBL4714125 | 0.82 | GPR119 (0.62) | GPR119 | |
| SCHEMBL2774561 | 0.82 | GPR119 (0.51) | GPR119NPBWR1MCHR1 | |
| SCHEMBL2774875 | 0.82 | GPR119 (0.51) | GPR119NPBWR1MCHR1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017123542-A1 | SUBSTITUTED THIOHYDANTOIN DERIVATIVES AS ANDROGEN RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2017-07-20 | — | — | WO | disclosed |