Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 17/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19128592 | 0.82 | ROCK2 (0.41) | ROCK2PLAT | |
| SCHEMBL23889037 | 0.81 | ROCK2 (0.41) | ROCK2PLAT | |
| SCHEMBL20654134 | 0.80 | ROCK2 (0.49) | ROCK2 | |
| SCHEMBL19127952 | 0.80 | SPR (0.43) | ROCK2PLAT | |
| SCHEMBL21947213 | 0.80 | PLAT (0.39) | ROCK2PLAT | |
| SCHEMBL20646828 | 0.79 | ROCK2 (0.40) | ROCK2PLAT | |
| SCHEMBL20653915 | 0.78 | ROCK2 (0.39) | ROCK2 | |
| SCHEMBL24247767 | 0.77 | PLAT (0.41) | ROCK2PLAT | |
| SCHEMBL21947357 | 0.70 | ROCK2 (0.41) | ROCK2 | |
| SCHEMBL23888982 | 0.70 | ERN1 (0.34) | DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017123860-A1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-07-20 | — | — | WO | disclosed |