Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19150044 | 0.77 | ROCK2 (0.34) | ROCK2 | |
| SCHEMBL17454485 | 0.73 | KDM4E (0.41) | ROCK2 | |
| SCHEMBL17437829 | 0.73 | KDM4E (0.41) | ROCK2 | |
| SCHEMBL19150034 | 0.72 | XDH (0.35) | ROCK2 | |
| SCHEMBL17454409 | 0.71 | ROCK2 (0.39) | ROCK2 | |
| SCHEMBL17438010 | 0.71 | ROCK2 (0.39) | ROCK2 | |
| SCHEMBL17454433 | 0.70 | ROCK2 (0.43) | ROCK2 | |
| SCHEMBL21946607 | 0.70 | ROCK2 (0.38) | ROCK2 | |
| SCHEMBL19128171 | 0.70 | ROCK2 (0.39) | ROCK2 | |
| SCHEMBL17437994 | 0.70 | ROCK2 (0.42) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017123860-A1 | SPIROHEPTANE SALICYLAMIDES AND RELATED COMPOUNDS AS INHIBITORS OF ROCK | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-07-20 | — | — | WO | disclosed |