SCHEMBL19154331

SCHEMBL19154331

COc1ccc(CN2CC3(CCC(c4ccccc4)CC3)N(CC3CCC3)C2=O)cc1

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
OPRM1 P35372 20/20 0.73
OPRL1 P41146 18/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19149772 0.88 OPRM1 (0.76) OPRM1OPRL1
SCHEMBL19154316 0.87 OPRM1 (0.63) OPRM1OPRL1
SCHEMBL19151581 0.86 OPRL1 (0.70) OPRM1OPRL1
SCHEMBL19145831 0.85 OPRM1 (0.69) OPRM1OPRL1
SCHEMBL19093754 0.85 OPRM1 (0.75) OPRM1OPRL1
SCHEMBL19093784 0.84 OPRM1 (1.00) OPRM1OPRL1
SCHEMBL19104811 0.84 OPRM1 (1.00) OPRM1OPRL1
SCHEMBL19093782 0.84 OPRM1 (1.00) OPRM1OPRL1
SCHEMBL19106747 0.84 OPRM1 (0.67) OPRM1OPRL1
SCHEMBL19096644 0.83 OPRM1 (1.00) OPRM1OPRL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017121646-A1 3-(CARBOXYETHYL)-8-AMINO-2-OXO-1,3-DIAZA-SPIRO-[4.5]-DECANE DERIVATIVES Grünenthal GmbH (DE) 2017-07-20 WO disclosed