Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.64 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.64 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15276915 | 0.92 | LMNA (0.60) | LMNAPTBP1CA12CA1CA9 | |
| SCHEMBL15276916 | 0.90 | LMNA (0.58) | LMNAPTBP1CA12CA1CA9 | |
| SCHEMBL18948462 | 0.89 | LMNA (0.69) | LMNACA12CA1CA9MAPT | |
| SCHEMBL15276914 | 0.81 | LMNA (0.58) | LMNAPTBP1CA12CA1CA9 | |
| SCHEMBL15276900 | 0.81 | LMNA (0.67) | LMNAPTBP1CA12CA1CA9 | |
| SCHEMBL15276896 | 0.77 | LMNA (0.55) | LMNAPTBP1MAPTALDH1A1MEN1 | |
| SCHEMBL15276891 | 0.77 | LMNA (0.70) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL18947633 | 0.76 | MAPT (0.52) | LMNACA12CA1CA9MAPT | |
| SCHEMBL15276793 | 0.76 | SIRT2 (0.54) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL15276892 | 0.76 | MAPT (0.56) | LMNAMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3312160-B1 | HEPATITIS B ANTIVIRAL AGENTS | NOVIRA THERAPEUTICS INC (US) | 2020-03-18 | — | — | EP | disclosed |
| EP-2794565-B1 | HEPATITIS B ANTIVIRAL AGENTS | NOVIRA THERAPEUTICS INC (US) | 2017-07-26 | — | — | EP | disclosed |