Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPBWR1 | P48145 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16244426 | 0.92 | NPBWR1 (0.42) | NPBWR1TDP1MAPTPOLBABCB1 | |
| SCHEMBL19159167 | 0.91 | TDP1 (0.37) | NPBWR1TDP1MAPTPOLBABCB1 | |
| SCHEMBL16244484 | 0.88 | TDP1 (0.39) | NPBWR1TDP1ABCB1KMT2ACNR2 | |
| SCHEMBL16244627 | 0.85 | NPBWR1 (0.42) | NPBWR1MAPTPOLBABCB1KMT2A | |
| SCHEMBL16244388 | 0.83 | ABCB1 (0.37) | TDP1ABCB1KMT2ACNR2RXFP1 | |
| SCHEMBL16244695 | 0.79 | PDE4A (0.40) | NPBWR1MAPTPOLBKMT2AP2RX3 | |
| SCHEMBL16259906 | 0.76 | KDM4E (0.39) | NPBWR1TDP1MAPTP2RX3ALDH1A1 | |
| SCHEMBL16244935 | 0.76 | KMT2A (0.41) | NPBWR1TDP1KMT2AALDH1A1HPGD | |
| SCHEMBL16244757 | 0.74 | P2RX3 (0.41) | NPBWR1MAPTP2RX3L3MBTL1BRD4 | |
| SCHEMBL19158727 | 0.73 | BRD4 (0.34) | ABCB1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3004110-B1 | PYRAZOLOPYRROLIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2017-07-26 | — | — | EP | disclosed |