Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 15/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19173722 | 0.92 | HSD11B1 (0.65) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR | |
| SCHEMBL19148532 | 0.89 | HSD11B1 (0.64) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR | |
| SCHEMBL19150618 | 0.87 | HSD11B1 (0.86) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR | |
| SCHEMBL19174080 | 0.83 | HSD11B1 (0.80) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR | |
| SCHEMBL19173738 | 0.83 | HSD11B1 (0.80) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR | |
| SCHEMBL19173313 | 0.80 | HSD11B1 (0.82) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR | |
| SCHEMBL19173935 | 0.80 | HSD11B1 (1.00) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR | |
| SCHEMBL19173256 | 0.77 | HSD11B1 (0.51) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR | |
| SCHEMBL23489226 | 0.77 | HSD11B1 (0.66) | HSD11B1ALDH1A1SMN1; SMN2TSHRHTT | |
| SCHEMBL19248163 | 0.77 | HSD11B1 (1.00) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017127306-A1 | ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTION | ARISAN THERAPEUTICS (US) | 2017-07-27 | — | — | WO | disclosed |