Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 17/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19174080 | 0.96 | HSD11B1 (0.80) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR | |
| SCHEMBL19173738 | 0.96 | HSD11B1 (0.80) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR | |
| SCHEMBL19173313 | 0.93 | HSD11B1 (0.82) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR | |
| SCHEMBL19173935 | 0.93 | HSD11B1 (1.00) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR | |
| SCHEMBL19173546 | 0.87 | HSD11B1 (0.67) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR | |
| SCHEMBL19173722 | 0.85 | HSD11B1 (0.65) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR | |
| SCHEMBL19148532 | 0.84 | HSD11B1 (0.64) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR | |
| SCHEMBL19173683 | 0.84 | HSD11B1 (0.64) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR | |
| SCHEMBL19173688 | 0.84 | HSD11B1 (0.63) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR | |
| SCHEMBL19173468 | 0.83 | ALDH1A1 (0.98) | HSD11B1ALDH1A1SMN1; SMN2MEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3405183-A1 | ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTION | Arisan Therapeutics Inc. (US) | 2018-11-28 | — | — | EP | disclosed |
| WO-2017127306-A1 | ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTION | ARISAN THERAPEUTICS (US) | 2017-07-27 | — | — | WO | disclosed |
| WO-2017127306-A1 | ADAMATANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTION | ARISAN THERAPEUTICS (US) | 2017-07-27 | — | — | WO | disclosed |