Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.70 |
| ▸ | TP53 | P04637 | 4/20 | 0.70 |
| ▸ | RAB9A | P51151 | 11/20 | 0.69 |
| ▸ | NPC1 | O15118 | 10/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.69 |
| ▸ | GAA | P10253 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | GFER | P55789 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13325910 | 0.86 | SMN1; SMN2 (0.93) | SMN1; SMN2TP53RAB9ANPC1KDM4E | |
| SCHEMBL4727262 | 0.85 | NPC1 (0.73) | SMN1; SMN2TP53RAB9ANPC1KDM4E | |
| SCHEMBL4727102 | 0.85 | SMN1; SMN2 (0.79) | SMN1; SMN2TP53RAB9ANPC1KDM4E | |
| SCHEMBL1691995 | 0.83 | SMN1; SMN2 (1.00) | SMN1; SMN2TP53RAB9ANPC1KDM4E | |
| SCHEMBL19149758 | 0.82 | TLR9 (0.60) | SMN1; SMN2TP53RAB9ANPC1KDM4E | |
| SCHEMBL6389122 | 0.82 | SMN1; SMN2 (0.74) | SMN1; SMN2TP53RAB9ANPC1KDM4E | |
| SCHEMBL26689119 | 0.82 | NPC1 (0.72) | SMN1; SMN2TP53RAB9ANPC1KDM4E | |
| SCHEMBL972809 | 0.82 | NPC1 (1.00) | SMN1; SMN2TP53RAB9ANPC1KDM4E | |
| SCHEMBL4727165 | 0.82 | SMN1; SMN2 (0.79) | SMN1; SMN2TP53RAB9ANPC1KDM4E | |
| SCHEMBL27097316 | 0.82 | NPC1 (0.47) | SMN1; SMN2TP53RAB9ANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11912699-B2 | Tau-protein targeting compounds and associated | ARVINAS OPERATIONS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| WO-2017127627-A1 | COMPOUNDS FOR TREATMENT OF TRYPANOSOMES AND NEUROLOGICAL PATHOGENS AND USES THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2017-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11912699-B2 | Tau-protein targeting compounds and associated | MAPT, VHL, CRBN | SMN1; SMN2 1058/4885TP53 78/4885RAB9A 1429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.