Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.73 |
| ▸ | RAB9A | P51151 | 12/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.73 |
| ▸ | MAPT | P10636 | 6/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | PKM | P14618 | 4/20 | 0.66 |
| ▸ | TP53 | P04637 | 4/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.61 |
| ▸ | RELA | Q04206 | 3/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6390132 | 0.88 | RAB9A (0.71) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL19174232 | 0.85 | SMN1; SMN2 (0.70) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL4725053 | 0.84 | RAB9A (1.00) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL16212126 | 0.84 | NPC1 (0.61) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL4728826 | 0.83 | RAB9A (0.76) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL13325910 | 0.80 | SMN1; SMN2 (0.93) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL6544442 | 0.80 | NPC1 (1.00) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL4727102 | 0.79 | SMN1; SMN2 (0.79) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6545323 | 0.79 | NPC1 (0.97) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| Bromide SCHEMBL5313495 | 0.78 | HRH3 (0.72) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008029152-A2 | TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | SUMMIT CORPORATION PLC (GB) | 2008-03-13 | — | — | WO | disclosed |