Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | GSR | P00390 | 6/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4889799 | 0.78 | GSR (0.39) | GSRALDH1A1CA2 | |
| SCHEMBL5155736 | 0.74 | GSR (0.31) | GSR | |
| SCHEMBL28921029 | 0.73 | — | — | |
| SCHEMBL8957333 | 0.73 | GSR (0.50) | GSRALDH1A1CA2 | |
| SCHEMBL9330340 | 0.73 | SMN1; SMN2 (0.40) | GSRALDH1A1 | |
| SCHEMBL9332527 | 0.73 | HRH3 (0.37) | GSR | |
| SCHEMBL5155730 | 0.73 | GSR (0.30) | GSR | |
| SCHEMBL21524679 | 0.72 | GSR (0.38) | GSRALDH1A1CA2 | |
| SCHEMBL9330677 | 0.70 | HRH3 (0.40) | — | |
| SCHEMBL680053 | 0.70 | HSD11B1 (0.35) | ATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326652-A1 | NITRO DERIVATIVES OF FURASEMIDE AND THEIR USE AS DIURETICS | Merck Sharp & Dohme Corp. (US) | 2011-06-01 | — | — | EP | disclosed |
| WO-2010014516-A1 | NITRO DERIVATIVES OF FURASEMIDE AND THEIR USE AS DIURETICS | MERCK & CO., INC. (US) | 2010-02-04 | — | — | WO | disclosed |